Direct Asymmetric Vinylogous Mannich Reaction of 3,4-Dihalofuran-2(5H)?one with Aldimine Catalyzed by Quinine

摘要

The direct asymmetric vinylogous Mannichnreaction of 3,4-dihalofuran-2(5H)-one with aldimine catalyzednby quinine was first reported, and γ-butenolides have beennobtained in excellent yield (up to 98%) and enantioselectivitiesn(up to 95% ee). The synthetic applications of this protocol arendemonstrated in the preparations of γ-substituted aminonbutyrolactones and vicinal amino alcohols.