Three-Component, One-Pot Sequential Synthesis of Functionalized Cyclazines: 3H?1,2a1,3-Triazaacenaphthylenes

摘要

An efficient tandem route to the synthesis ofn3H-1,2a1,3-triazaacenaphthylene derivatives of the cyclazinenfamily has been developed. Target compounds were obtainednin moderate to good yields by a Yb(OTf)3/Ag2CO3-catalyzed,nthree-component domino reaction. This in turn will set thenstage for a wide application of this useful reaction for thensynthesis of structurally diverse polyheterocyclic skeletonsncontaining the imidazo[1,2-a]pyridine privileged structure.