Synthesis and Stability of Phosphate Modified ATP Analogues

摘要

Nucleotides modified at the phosphate havennumerous applications. Nevertheless, the number of attachmentnmodes is limited and little is known about their stability.nHere, we present results on the elaboration of the synthesis ofnfive classes of ATP analogues and studies concerning theirnstability. We show that the nitrogen-linked ATP analogue isnless stable, whereas the oxygen- and novel carbon-linked adenosine tri- and tetraphosphate analogues are stable from pH 3 to 12nrendering them interesting for further applications and designs.