Synthesis of Polycyclic Isoindoline Derivatives via Tandem Pd-Catalyzed Coupling, Propargyl?Allenyl Isomerization, [4 + 2] Cycloaddition and Aromatization Reaction

摘要

We report in this paper an interestingnsequential reaction involving sequential Sonogashira coupling,npropargyl−allenyl isomerization, [4 + 2] cycloaddition andnaromatization reaction, which provides a facile method for thensynthesis of a variety of polycyclic isoindoline derivatives fromneasily accessible starting materials.