Synthesis of Aryl Thioethers through the N?Chlorosuccinimide-Promoted Cross-Coupling Reaction of Thiols with Grignard Reagents

摘要

A convenient one-pot approach for the synthesis of arylnsulfides through the coupling of thiols with Grignard reagents in thenpresence of N-chlorosuccinimide is described. The sulfenylchlorides werenformed when thiols were treated with N-chlorosuccinimide, and thenresulting sulfenylchlorides were then directly reacted with Grignardnreagents to provide aryl sulfides in good to excellent yields under mildnreaction conditions. Functional groups including ester, fluoro, and chloro are tolerated by the reaction conditions employed. It isnimportant to note that this method has a short reaction time (30 min in total) and represents an alternative approach for thensynthesis of aryl sulfides over the existing protocols.