Synthesis of Cyclic Peptides Containing a Thioester Handle for Native Chemical Ligation

摘要

The synthesis of cyclic peptides containing a thioester handle using a sulfoclicknlinker is reported. These cyclic peptides can be coupled to N-terminal cysteinecontainingnconstructs via native chemical ligation. A successful application of a cyclicnpeptide bearing a thioester handle in native chemical ligation is shown by a high yieldingnligation.