Preparation of Trifluorostyrenes via Palladium-Catalyzed Coupling of Arylboronic Acids with Chloro- and Bromotrifluoroethylene

摘要

A highly efficient and cost-effective method for thenpreparation of α,β,β-trifluorostyrene (TFS) and its derivatives is described.nThe method required only 0.2 mol % of Pd(dba)2 and 0.4 mol % of PtBu3nand occurred to full conversion within 2.0 h. With this method, a wide rangenof arylboronic acids were efficiently incorporated to generate α,β,β-ntrifluorostyrene derivatives.