Clinic-Based Treatment of Opioid-Dependent HIV-Infected Patients Versus Referral to an Opioid Treatment Program: A Randomized Trial

摘要

Background: Opioid dependence is common in HIV clinics. Buprenorphine–naloxone (BUP) is an effective treatment of opioid dependence that may be used in routine medical settings. nnObjective: To compare clinic-based treatment with BUP (clinic-based BUP) with case management and referral to an opioid treatment program (referred treatment). nnDesign: Single-center, 12-month randomized trial. Participants and investigators were aware of treatment assignments. (ClinicalTrials.gov registration number: NCT00130819) nnSetting: HIV clinic in Baltimore, Maryland. nnPatients: 93 HIV-infected, opioid-dependent participants who were not receiving opioid agonist therapy and were not dependent on alcohol or benzodiazepines.