Basic fibroblast growth factor and hepatocyte growth factor content of wound, repair, and muscle regeneration fluids

摘要

Injury produces marked changes to the local environment. Changes in both diversity and availability of bioactive substances at wound sites might discriminate between repair and regeneration microenvironments and selectively drive events leading to final resolution. Among factors with potential relevance to wound repair and regeneration are basic fibroblast growth factor (bFGF) and hepatocyte growth factor (HGF). In this study, concentrations of these factors were determined in fluids derived from wound, repair, and regeneration-conditioned models using enzyme-linked immunosorbent assays.