Expression and significance of PTEN and PCNA in human laryngeal squa-mous cell carcinoma

摘要

Objective: To elucidate the expression and significance of PTEN and PCNA in human laryngeal squamous cell carcinoma. Methods: Immunochemical method was used to study 60 cases of laryngeal carcinoma, 20 cases of normal laryngeal tissues which were closely adjacent to carcinoma and 10 cases of normal laryngeal tissues. Results: It was showed that PTEN gene was expressed in 85% laryngeal carcinoma tissues. The percentage of lymph node metastasis oi laryngeal carcinoma which were negative or positive of PTEN protein was 77 . 8 % and 33 . 3 % respectively, and the difference was significance ( P < 0.05) . Conclusion: Expression of PTEN in laryngeal carcinoma was different from that of normal laryngeal tissues. It may play a role but not important in the tumorigenesis and development of laryngeal carcinoma.