Association between estrogen receptor β gene Rsal polymorphism and depressive disorder in peri-menopausal and menopausal women

摘要

Objective: To investigate estrogen receptor β (ERβ) gene Rsal polymorphism and concentration of estrogen, FSH and LH in serum in peri-menopausal and menopausal women with depressive disorder. Methods: Seventy-four peri-menopausal and menopausal women with depressive disorder met ICD-10 and CCMD-3 assessment criteria for depressive disorder were recruited. ERβ gene Rsal polymorphism was analyzed with PCR-RFLP. Serum levels of estrogen, FSH and LH were measured by magnetism-ELISA. Results: The respective frequency of ERβ gene Rsal polymorphism was no significant difference between women with depressive disorder and the healthy women (χ~2 = 1.106, P>0. 05). The serum level of estrogen was lower in women with depressive disorder than in the healthy women (P<0. 05). No difference was found for FSH and LH between two groups. Conclusion: ERβ gene Rsal polymorphism may be not associated with depressive disorder in the peri-menopausal and menopausal women. The serum level of estrogen is associated with depressive disorder in the peri-menopausal and menopausal women.