卵巣摘出ラットにおける牛乳•乳製品摂取による骨密度ならびに組織中アル力リホスファターゼ活性に及ぼす影響について

摘要

We examined effect of milk and dairy products on the bone mineral density (BMD) and alkaline phosphatase (ALP) activity of ovariectomized rats. Female rats were ovariectomized (OVX), and other rats received a sham operation. The OVX rats were assigned to 4 dietary groups: the control (OVX-Cont.) group, skimmed milk (OVX-Milk) group, fermented milk (OVX-Yogurt) group, and whey (OVX-Whey) group. Eighty-four days after feeding the experimental diets, the BMD level of the femur was significantly higher in the OVX-Milk and OVX-Whey groups than in the OVX-Cont. group. The level of serum ALP activity was significantly lower in the OVX-Cont. group than in the OVX-Milk and OVX-Yogurt groups. These results imply that milk or dairy products improved the BMD level, and had an effect on the ALP activity of OVX rats.%我が国では急速な高齢化に伴い，骨粗鬆症患者が年々増加し，男女合わせた患者数は1280万人と推定されている.骨粗鬆症は，遺伝因子や長年の生活習慣など，種々の因子により発症し，「骨強度の低下を特徴とし，骨折のリスクが増大しやすくなる骨格疾患」と定義されている.