高空問分解能Multiple Echo Planar Imaging Based Signal Targeting and Alternating Radiofrequencyによる頭蓋内非造影Time-resolved MR Angiography

摘要

脳動静脈奇形やもやもや病など脳血管障害の診断と治療には，詳細な血管構築と血行動態の把握が必要であり，特に，側副循環の識別は再発する脳卒中の危険性評価に重要である．血管構築評価に関してはmagnetic resonance imaging（MRI）によるtime-of-flight（TOF）法やphase-contrast（PC）法が有用とされ，血行動態に対する機能評価においては高い空間分解能と時間分解能を有したX線ディジタルサブトラクション血管造影法やmagnetic resonance digital subtraction angiography（MRDSA）が有用とされている．%Detailed information on anatomy and hemodynamics in cerebrovascular disorders such as AVM and Moyamoya disease is mandatory for defined diagnosis and treatment planning. Arterial spin labeling technique has come to be applied to magnetic resonance angiography (MRA) and perfusion imaging in recent years. However, those non-contrast techniques are mostly limited to single frame images. Recently we have proposed a non-contrast time-resolved MRA technique termed contrast inherent inflow enhanced multi phase angiography combining spatial resolution echo planar imaging based signal targeting and alternating radiofrequency (CINEMA-STAR). CINEMA-STAR can extract the blood flow in the major intracranial arteries at an interval of 70 ms and thus permits us to observe vascular construction in full by preparing MIP images of axial acquisitions with high spatial resolution. This preliminary study demonstrates the usefulness of the CINEMA-STAR technique in evaluating the cerebral vasculature.