The Sweet Smell of Success: Conclusive Evidence that Cyclic AMP Hydrolysis Does Not Trigger Fast Adaptation in Olfactory Receptor Cells

摘要

We are often taught that it is almost impossible to publish negative results. Yet, in this issue, Boccaccio, Lagostena, Hagen, and Menini (2006) have assembled a very impressive array of negative results that answer a critical question in olfactory transduction. In an elegant set of experiments, these authors have ruled out a suspected mechanism of fast olfactory adaptation and have, by default, provided further evidence for another mechanism in the process.