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Effect of methylmercury on some neurotransmitters and oxidative damage of rats

机译:甲基汞对大鼠某些神经递质和氧化损伤的影响

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In order to study the molecular mechanism of injury in rat organs induced by methylmercury, and the relationship between neurotransmitter and oxidative damage in the toxicity process of rat injury by methylmercury was studied. The control group was physiological saline of 0.9 percent, the concentration of exposure groups were 5 mg/(kg-d) and 10 mg/(kg-d) respectively. The content of AChE, ACh, NOS, NO, MDA, SOD, GSH-Px and GSH in different organs of rats were determined with conventional methods. The results showed that after exposure to methylmercury for 7 d, the mercury content in brain of exposure groups increased clearly and had significant difference compared with the control group( P < 0.01). In rat's brain, serum, liver and kidney, the content of ACh and AChE were all decreased; the content of NOS and NO were all increased; the content of MDA was increased compared with the control group, the exposure groups had significant difference ( P < 0.01); the content of SOD, GSH and GSH-Px was decreased compared with the control group, the exposure groups had significant difference( P<0.01). It could be concluded that methylmercury did effect the change of neurotransmitter and free radical. They participated in the toxicity process of injury by methylmercury. The damage of neurotransmitter maybe cause the chaos of free radical and the chaos of free radical may also do more damage to neurotransmitter vice versa.
机译:为了研究甲基汞致大鼠器官损伤的分子机制,研究了甲基汞致大鼠毒性过程中神经递质与氧化损伤的关系。对照组为0.9%的生理盐水,暴露组浓度分别为5 mg /(kg-d)和10 mg /(kg-d)。用常规方法测定大鼠不同器官中AChE,ACh,NOS,NO,MDA,SOD,GSH-Px和GSH的含量。结果表明,甲基汞暴露7 d后,暴露组脑中汞含量明显增加,与对照组相比差异有统计学意义(P <0.01)。在大鼠的脑,血清,肝和肾中,ACh和AChE的含量均降低; NOS和NO含量均增加; MDA含量较对照组增加,接触组差异有统计学意义(P <0.01)。 SOD,GSH,GSH-Px的含量较对照组降低,接触组差异有统计学意义(P <0.01)。可以得出结论,甲基汞确实影响了神经递质和自由基的变化。他们参与了甲基汞伤害的毒性过程。神经递质的破坏可能引起自由基的混乱,自由基的混乱也可能对神经递质造成更大的损害,反之亦然。

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