STUDIES ON PHARMACODYNAMIC ACTION OF N-ETHYLMALEIMIDE (NEM)

摘要

References(14) Intraperitoneal injection of NEM to rats, produced marked hyperglycemia, a considerable decrease in liver glycogen and inhibition of glucose uptake in skeletal muscles. It is postulated that these phenomena are due to the acceleration of sugar mobilization from liver glycogen, inhibition of glucose utilization in peripheral organ tissues, and partial mediation of epinephrine released from adrenal medulla. NEM reacted quickly with red cells but not with plasma protein and was inactivated or taken up into red cells, the reason being that when NEM is administered i.v. the action is much weaker.