lsolation and Structural Analysis of Antihypertensive Peptides That Exist Naturally in Gouda Cheese

摘要

Seven kinds of ripened cheeses (8-mo-aged and 24- mo-aged Gouda, Emmental, Blue, Camembert, Edam, and Havarti) were homogenized with distilled water, and water-soluble peptides were prepared by C-18 hy- drophobic chromatography. The inhibitory activity to angiotensin I-converting enzyme and decrease in the systolic blood pressure in spontaneously hypertensive rats were measured before and after oral administra- tion of each peptide sample. The strongest depressive effect in the systolic blood pressure (-24.7 mm Hg) and intensive inhibitory activity to angiotensin I-converting enzyme (75.7/100) were detected in the peptides from 8- mo-aged Gouda cheese.