Can vacuum morphologies predict solubility and intrinsic dissolution rate? A case study with felodipine polymorph form IV

摘要

The impact of felodipine (Fel) polymorphism on vacuum morphology was studied and correlated with the structural properties like solubility and intrinsic dissolution rate (IDR). A correlation was established between solubility and IDR of three Fel polymorphs with their BFDH aspect ratio, growth morphology aspect ratio and polaron polar ratio. The predicted solubility and IDR values for form IV by three methods were in agreement, however, morphology growth aspect ratio model showed better prediction capability due to its higher coefficient of determination. The solubility for form IV was 0.0154 moll(-1) while the IDR was 0.246 mg min cm(-2) for growth morphology aspect ratio. (C) 2015 Elsevier B.V. All rights reserved.