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Use of tissue ink to maintain identification of individual cores on needle biopsies of the prostate

机译:使用薄纸墨水保持对前列腺穿刺活检的单个核的识别

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Background: There is an increasing necessity to extract the maximum amount of information, beyond even a cancer diagnosis, from prostate biopsies. Thus, maintaining site-specific information regarding individual biopsy cores might be critical. Aim: To evaluate the applicability of employing tissue ink to maintain the identity of individual prostatic biopsy cores. Method: In this ongoing study, 12 core prostate biopsy specimens are sent to the laboratory in individual pots labelled according to anatomical site. The specimens are placed in two separate multi-compartment cassettes. They are inked with different colours to identify the site of origin from each lobe. The cassettes are then processed with a single paraffin block for each side; the six cores from each side can be mounted on a single slide. Results: The different colours used adhere well to the biopsy cores, thus maintaining the identity of each core. Six cores from each side are embedded in a single paraffin block and examined on a single slide, making it cost-effective, while maintaining high quality, accurate histopathological information. Conclusion: Differential inking of prostate biopsy cores is an easily applicable method that is cost-effective and provides tumour location information. Prostate biopsy data archived to maintain individual core information might be used to determine applicability of such information to predict extra-capsular extension by correlating with imaging and radical prostatectomy findings, and for treatment planning.
机译:背景:从前列腺活检中提取最大量信息(甚至是癌症诊断信息)的必要性越来越高。因此,维护有关单个活检核心的特定于站点的信息可能至关重要。目的:评估采用组织墨水保持各个前列腺活检芯身份的适用性。方法:在这项正在进行的研究中,将12个核心前列腺活检标本送入实验室,并根据解剖部位贴上标签。将标本放置在两个单独的多隔室盒中。它们涂有不同的颜色,以识别每个叶的起源位置。然后用单侧石蜡块对盒进行处理。每个侧面的六个磁芯可以安装在一个滑轨上。结果:所使用的不同颜色很好地粘附于活检芯,从而保持每个芯的身份。每侧的六个核均嵌入单个石蜡块中,并在单个载玻片上进行检查,从而使其具有成本效益,同时保持了高质量,准确的组织病理学信息。结论:前列腺活检芯的差异供墨是一种易于应用的方法,具有成本效益并提供了肿瘤位置信息。存档以维护个别核心信息的前列腺活检数据可用于确定此类信息的适用性,以通过与影像学和前列腺癌根治术的相关结果进行关联来预测包膜外扩展,并用于治疗计划。

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