Synthesis of 2-(Alkylthio)-1,2,4-triazolo[1,5-a] pyrimidines and 3-(Alkythio)-1,2,4-triazolo[3,4]-a] pyrimidines and Their Vasodilator Activity

摘要

A series of new 2-(alkylthio)-5,7-dimethyl-1,2,4-triazolo[1,5-a] pyrimidines and 3-(alkylthio)-5,7-dimethyl-1,2,4-triazolo[3,4-a] pyrimidiens have been synthesized. These derivatives were evaluated for inhibitory effects on 85.7 mmol·L~-1 K~+ and 10~-4 mmol·L~-1 NE (nor-epinephrine)- induced contraction of rat aorta strips.