Thermodynamic Studies on Amino Acid Solvation in Aqueous Urea

摘要

The present paper discusses the behaviour of transfer free energy of some amino acids from water to 4M, 6M and 8M aqueous urea. Dissection of transfer free energy into cavity term, interaction term and electrical term reveals that cavity forming free energy of transfer ΔG_t~0 (cav) plays an important role in dictating actual interaction of amino acids in aqueous urea. Cavity forming free energy of transfer has been estimated by using Scaled Particle Theory (SPT).