...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of Cancer Research and Clinical Oncology >A single nucleotide polymorphism in the MMP-9 promoter affects tumor progression and invasive phenotype of gastric cancer
【24h】

A single nucleotide polymorphism in the MMP-9 promoter affects tumor progression and invasive phenotype of gastric cancer

机译：MMP-9启动子中的单核苷酸多态性影响胃癌的肿瘤进展和侵袭性表型

获取原文
获取原文并翻译 | 示例
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Matrix metalloproteinase-9 (MMP-9, gelatinase B) plays a key role in cancer invasion and metastasis by degradating the extracellular matrix (ECM) and basement membrane barriers. A cytosine (C)-thymidine (T) single nucleotide polymorphism (SNP) at position –1562 in the MMP-9 promoter is reported to affect expression of this gene. The purpose of this study was to investigate the relation between the –1562 C/T polymorphism and the development and progression of gastric cancer.
机译：基质金属蛋白酶9（MMP-9，明胶酶B）通过降解细胞外基质（ECM）和基底膜屏障，在癌症侵袭和转移中起关键作用。据报道，MMP-9启动子–1562位的胞嘧啶（C）-胸苷（T）单核苷酸多态性（SNP）影响该基因的表达。这项研究的目的是调查–1562 C / T多态性与胃癌的发生和发展之间的关系。

著录项

  • 来源
  • 作者

    Shunji Matsumura; Naohide Oue; Hirofumi Nakayama; Yasuhiko Kitadai; Kazuhiro Yoshida; Yoshiyuki Yamaguchi; Kazue Imai; Kei Nakachi; Keisuke Matsusaki; Kazuaki Chayama; Wataru Yasui;

  • 作者单位

    Department of Molecular Pathology Hiroshima University Graduate School of Biomedical Sciences;

    Department of Molecular Pathology Hiroshima University Graduate School of Biomedical Sciences;

    Department of Molecular Pathology Hiroshima University Graduate School of Biomedical Sciences;

    Department of Medicine and Molecular Science Hiroshima University Graduate School of Biomedical Sciences;

    Department of Surgical Oncology Research Institute for Radiation Biology and Medicine Hiroshima University;

    Department of Surgical Oncology Research Institute for Radiation Biology and Medicine Hiroshima University;

    Department of Radiobiology/Molecular Epidemiology Radiation Effects Research Foundation;

    Department of Radiobiology/Molecular Epidemiology Radiation Effects Research Foundation;

    Department of Surgery Hofu Institute of Gastroenterology;

    Department of Medicine and Molecular Science Hiroshima University Graduate School of Biomedical Sciences;

    Department of Molecular Pathology Hiroshima University Graduate School of Biomedical Sciences;

  • 收录信息
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    MMP-9; SNP; Gastric cancer; Depth of tumor invasion; Lymphatic invasion;

    机译：MMP-9;SNP;胃癌;肿瘤浸润深度;淋巴管浸润;

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号