Induction of Fas (CD95/APO-1) ligand is essential for p53-dependent apoptosis in an in vitro renal carcinoma model system

Toshihiko Okazaki; Daitoku Sakamuro

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Induction of Fas (CD95/APO-1) ligand is essential for p53-dependent apoptosis in an in vitro renal carcinoma model system

机译：Fas（CD95 / APO-1）配体的诱导对于体外肾癌模型系统中p53依赖性细胞凋亡至关重要

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The Fas/CD95/APO-1 ligand (FasL) is a death cytokine that binds to cell surface Fas/CD95/APO-1 receptor, yet a possible role of FasL expression in p53-dependent apoptosis is not fully understood in many human malignancies, including renal carcinoma.

机译：Fas / CD95 / APO-1配体（FasL）是一种与细胞表面Fas / CD95 / APO-1受体结合的死亡细胞因子，但是在许多人类恶性肿瘤中，FasL表达在p53依赖性细胞凋亡中的可能作用尚不完全清楚，包括肾癌。

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来源
《Journal of Cancer Research and Clinical Oncology 》 |2007年第9期| 581-588| 共8页
作者
Toshihiko Okazaki; Daitoku Sakamuro;
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作者单位

Walther Cancer Institute Purdue Cancer Center West Lafayette Indiana USA;

Department of Pathology School of Medicine and Stanley S. Scott Cancer Center Louisiana State University Health Sciences Center 533 Bolivar Street New Orleans LA 70112 USA;

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原文格式 PDF
正文语种 eng
中图分类
关键词
p53 tumor suppressor; Fas ligand; Fas receptor; Apoptosis; Transactivation; Renal carcinoma; c-Myc oncogene;

机译：p53抑癌因子;Fas配体;Fas受体;凋亡;反式激活;肾癌;c-Myc癌基因;

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专利

1. Mechanisms of neutrophil apoptosis in uremia and relevance of the Fas (APO-1, CD95)/Fas ligand system. [J] . Jaber BL, Perianayagam MC, Balakrishnan VS, Journal of Leukocyte Biology: An Official Publication of the Reticuloendothelial Society . 2001 ,第6期

机译：尿毒症中性粒细胞凋亡的机制以及Fas（APO-1，CD95）/ Fas配体系统的相关性。
2. Deficient activation of CD95 (APO-1/ Fas)-mediated apoptosis: a potential factor of multidrug resistance in human renal cell carcinoma [J] . U Ramp, M Dejosez, C Mahotka, British Journal of Cancer . 2000 ,第11期

机译：CD95（APO-1 / Fas）介导的细胞凋亡的激活不足：人类肾细胞癌多药耐药的潜在因素。
3. Hydrogen peroxide-induced apoptosis in human hepatoma cells is mediated by CD95(APO-1/Fas) receptor/ligand system and may involve activation of wild-type p53. [J] . Huang C, Li J, Zheng R, Molecular biology reports . 2000 ,第1期

机译：过氧化氢诱导的人肝癌细胞凋亡是由CD95（APO-1 / Fas）受体/配体系统介导的，可能涉及野生型p53的激活。
4. Modulation of CD95 (APO-1/Fas)-induced hepatocyte death by NO [C] . P. R. GALLE, D. STRAND, Z. SU, International Symposium on the Maillard Reaction . 2002

机译：CD95（APO-1 / Fas）的调节 - 诱导肝细胞死亡
5. Characterization of membrane Fas Ligand-associated microvesicles: A role in induction of both apoptosis and inflammation [D] . Subramanian, Deepa 2008

机译：膜Fas配体相关的微囊泡的表征：在诱导凋亡和炎症中的作用
6. Involvement of the CD95 (APO-1/Fas) receptor and ligand system in Helicobacter pylori-induced gastric epithelial apoptosis. [O] . J Rudi, D Kuck, S Strand, 1998

机译：CD95（APO-1 / Fas）受体和配体系统参与幽门螺杆菌诱导的胃上皮细胞凋亡。
7. Deficient activation of CD95 (APO-1/ Fas)-mediated apoptosis: a potential factor of multidrug resistance in human renal cell carcinoma [O] . Ramp, U, Dejosez, M, Mahotka, C, 2000

机译：CD95（APO-1 / Fas）介导的细胞凋亡的激活不足：人类肾细胞癌多药耐药的潜在因素。

Induction of Fas (CD95/APO-1) ligand is essential for p53-dependent apoptosis in an in vitro renal carcinoma model system

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