Conserved function and regulation ofσ~32 homologues in Gram-negative bacteria

摘要

The heat shock response in Escherichia coli and related bacteria is primarily mediated byσ~32 or its homologue (RpoH protein)specifically required for transcription of heat shock encoding molecular chaperones and proteases. Extensive work in E.coli revealed some of the mechanisms controlling the cellular level and activity ofσ~32 during the heat shock response. Recent isolation of a number of RpoH homologues fromγ, βandαproteobacteria provided an opportunity to examine evolutionary conservation and diversity of regulatory mechanisms in these bacteria.