Effect of γ-radiation on the ratio of [~18F]-2fluoro-2-deoxy-D-glucose to glucose utilization in human glioblastoma cells in vitro

摘要

The glucose consumption in tumours in vivo as reflected by uptake of [~18F]-2fluoro-2-deoxy-D-glucose (~18FDG) using positron emission tomography (PET) is currently under investigation as a measure of tumour response to radiotherapy. The calculation of cerebral metabolic rate of glucose from ~18FDG-PET data requires a proportionality factor referred to as the lumped constant. In the present in vitro study, the utilizations of ~18FDG and glucose have been measured in a human glioblastoma cell line (86HG-39) as a function of γ-radiation dose with various post-irradiation times and of different fractionation modes.