首页> 外文期刊>Journal of Biosciences >Serotonin_(1A) receptor agonist acquires an antimalarial connection
【24h】

Serotonin_(1A) receptor agonist acquires an antimalarial connection

机译:血清素_(1A)受体激动剂获得抗疟药连接

获取原文
获取原文并翻译 | 示例
       

摘要

Malaria is a major infectious disease. It affects over 100 million people worldwide in a year (Whitty el al 2002). In India alone, there are at least 2 million cases reported annually (Padmanaban 2003). The most severe form of the disease is caused by infection with the protozoan parasite Plasmodium falciparum leading to more than a million deaths a year (Whitty el al 2002). The morbidity and mortality are compounded by the spreading drug resistance to several existing malaria drugs. This has created an urgent need for novel drugs, which has become an important aspect of anti-malarial research (Biagini et al 2003). Since malaria is a highly complex, multifactorial disease, the spectrum of research activities for its prevention and management is vast. An interesting recent approach has been to target enzymes in the parasite necessary for biosynthesis of membrane components such as fatty acids (Bhat and Surolia 2001; Surolia and Surolia 2001) and sphingolipids (Lauer et al 1995). Serotonin (5-hydroxytryptamine or 5-HT) receptors are members of a super-family of seven trans-membrane domain receptors that couple to GTP-binding regulatory proteins (G-proteins). Seroto-nergic signalling appears to play a key role in the generation and modulation of various cognitive and behavioural functions. Among the types of serotonin receptors, the G-protein-coupled 5-HT_(1A) receptor subtype has been the most extensively studied (Harikumar et al 2000). One of the main reasons for this is the availability of a selective agonist, 8-hydroxy-2-(di-N-propylamino)tetralin (8-OH-DPAT), that allows extensive biochemical, physiological, and pharmacological characterization of the receptor (Arvidsson et al 1981; Gozlan et al 1983).
机译:疟疾是一种主要的传染病。一年中,它影响全球超过1亿人(Whitty等,2002)。仅在印度,每年至少报告200万例(Padmanaban 2003)。该病的最严重形式是由原生动物寄生虫恶性疟原虫感染导致的,每年导致超过一百万的死亡(Whitty等,2002)。耐药性扩散到几种现有的疟疾药物使发病率和死亡率更加复杂。这就迫切需要新药,这已成为抗疟疾研究的重要方面(Biagini等,2003)。由于疟疾是高度复杂的多因素疾病,因此预防和管理疟疾的研究活动范围很广。最近一种有趣的方法是在生物合成膜成分(例如脂肪酸(Bhat和Surolia,2001; Surolia和Surolia,2001))和鞘脂(Lauer等,1995)所需的寄生虫中靶向酶。血清素(5-羟色胺或5-HT)受体是七个跨膜结构域受体的超家族成员,它们与GTP结合调节蛋白(G蛋白)偶联。血清素能信号似乎在各种认知和行为功能的产生和调节中起关键作用。在5-羟色胺受体类型中,G蛋白偶联的5-HT_(1A)受体亚型已得到最广泛的研究(Harikumar等,2000)。造成这种情况的主要原因之一是选择性激动剂8-羟基-2-(二-N-丙基氨基)四氢化萘(8-OH-DPAT)的可用性,从而可以对该受体进行广泛的生化,生理和药理学表征(Arvidsson等,1981; Gozlan等,1983)。

著录项

  • 来源
    《Journal of Biosciences》 |2004年第1期|p.1-2|共2页
  • 作者单位

    Centre for Cellular and Molecular Biology, Uppal Road, Hyderabad 500 007, India;

  • 收录信息 美国《科学引文索引》(SCI);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 生物科学;
  • 关键词

  • 入库时间 2022-08-17 23:37:41

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱:kefu@zhangqiaokeyan.com

京公网安备:11010802029741号 ICP备案号:京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有
  • 客服微信

  • 服务号