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Enhanced analgesic effect of morphine-nimodipine combination after intraspinal administration as compared to systemic administration in mice

机译:与全身给药相比,脊髓内给药后吗啡-尼莫地平组合的镇痛作用增强

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摘要

Calcium plays an important role in the pathophysiology of pain. A number of studies have investigated the effect of L-type calcium channel blockers on the analgesic response of morphine. However, the results are conflicting. In the present study, the antinociceptive effect of morphine (2.5 microg) and nimodipine (1 microg) co-administered intraspinally in mice was observed using the tail flick test. It was compared to the analgesic effect of these drugs (morphine - 250 microg subcutaneously; nimodipine - 100 microg intraperitoneally) after systemic administration. Nimodipine is highly lipophilic and readily crosses the blood brain barrier. Addition of nimodipine to morphine potentiated the analgesic response of the latter when administered through the intraspinal route but not when administered through systemic route. It may be due to direct inhibitory effect of morphine and nimodipine on neurons of superficial laminae of the spinal cord after binding to mu -opioid receptors and L-type calcium channels respectively.
机译:钙在疼痛的病理生理中起重要作用。大量研究研究了L型钙通道阻滞剂对吗啡镇痛反应的影响。但是,结果是矛盾的。在本研究中,使用甩尾试验观察了吗啡(2.5微克)和尼莫地平(1微克)在脊髓内共同给药对小鼠的镇痛作用。将其与全身给药后这些药物的镇痛作用(吗啡-皮下250微克;尼莫地平-腹膜内100微克)的镇痛效果进行了比较。尼莫地平具有很高的亲脂性,可以轻易穿越血脑屏障。当通过脊髓内途径给药时,向吗啡中添加尼莫地平可增强后者的镇痛反应,但通过全身途径给药时则不能。这可能是由于吗啡和尼莫地平分别与μ阿片受体和L型钙通道结合后对脊髓浅层神经元的直接抑制作用。

著录项

  • 来源
    《Journal of Biosciences》 |2005年第4期|p.491-497|共7页
  • 作者

    Verma D; Ray SB; Patro I; Wadhwa S;

  • 作者单位

    Department of Anatomy, All India Institute of Medical Sciences, New Delhi 110 029, India.;

  • 收录信息 美国《科学引文索引》(SCI);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 生物科学;
  • 关键词

  • 入库时间 2022-08-17 23:37:30

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