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Amelioration of altered antioxidant status and membrane linked functions by vanadium and Trigonella in alloxan diabetic rat brains

机译:钒和Trigonella改善四氧嘧啶糖尿病大鼠脑中抗氧化剂状态和膜连接功能的改变

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Trigonella foenum graecum seed powder (TSP) and sodium orthovanadate (SOV) have been reported to have antidiabetic effects. However, SOV exerts hypoglycemic effects at relatively high doses with several toxic effects. We used low doses of vanadate in combination with TSP and evaluated their antidiabetic effects on anti-oxidant enzymes and membrane-linked functions in diabetic rat brains. In rats, diabetes was induced by alloxan monohydrate (15 mg/100 g body wt.) and they were treated with 2 IU insulin, 0.6 mg/ml SOV, 5% TSP and a combination of 0.2 mg/ml SOV with 5% TSP for 21 days. Blood glucose levels, activity of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), Na+/K+ ATPase, membrane lipid peroxidation and fluidity were determined in different fractions of whole brain after 21 days of treatment. Diabetic rats showed high blood glucose (P less than 0.001), decreased activities of SOD, catalase and Na+/K+ ATPase (P less than 0.01, P less than 0.001 and P less than 0.01), increased levels of GPx and MDA (P less than 0.01 and P less than 0.001) and decreased membrane fluidity (P less than 0.01). Treatment with different antidiabetic compounds restored the above-altered parameters. Combined dose of Trigonella and vanadate was found to be the most effective treatment in normalizing these alterations. Lower doses of vanadate could be used in combination with TSP to effectively counter diabetic alterations without any toxic effects.
机译:据报道,胡芦巴种子粉(TSP)和原钒酸钠(SOV)具有抗糖尿病作用。但是,SOV在较高剂量下具有降血糖作用,并具有多种毒性作用。我们将低剂量的钒酸盐与TSP结合使用,并评估了它们对糖尿病大鼠脑中抗氧化酶和膜连接功能的抗糖尿病作用。在大鼠中,四氧嘧啶一水合物(15 mg / 100 g体重)诱发糖尿病,并用2 IU胰岛素,0.6 mg / ml SOV,5%TSP和0.2 mg / ml SOV与5%TSP的组合治疗糖尿病持续21天。在治疗21天后,测定全脑不同部位的血糖水平,超氧化物歧化酶(SOD),过氧化氢酶(CAT),谷胱甘肽过氧化物酶(GPx),Na + / K + ATPase,膜脂质过氧化和流动性。糖尿病大鼠血糖高(P小于0.001),SOD,过氧化氢酶和Na + / K + ATPase活性降低(P小于0.01,P小于0.001和P小于0.01),GPx和MDA水平升高(P小于小于0.01,P小于0.001),膜流动性降低(P小于0.01)。用不同的抗糖尿病化合物治疗可以恢复上述参数。发现木犀草和钒酸盐的联合剂量是使这些改变正常化的最有效方法。较低剂量的钒酸盐可与TSP结合使用,以有效抵抗糖尿病的改变,而无任何毒性作用。

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