A lab-on-a-chip integrated microfluidic cell has been developed for magnetic biosensing, which is comprised of anisotropic magnetoresistance (AMR) sensors optimized for the detection of single magnetic beads and electrodes to manipulate and sort the beads, integrated into a microfluidic channel. The device is designed to read out the real-time signal from 9 μm diameter magnetic beads moving over AMR sensors patterned into 18 x 4.5 μm rectangles and 10 μm diameter rings and arranged in Wheatstone bridges. The beads are moved over the sensors along a 75 x 75 μm wide channel patterned in SU8. Beads of different magnetic moments can be sorted through a magnetostatic sorting gate into different branches of the microfluidic channel using a magnetic field gradient applied by lithographically denned 120 nm thick Cu striplines carrying 0.2 A current.
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机译：已经开发了一种芯片实验室集成微流控单元用于磁性生物传感，该单元由各向异性磁阻（AMR）传感器组成，该传感器经过优化，可检测单个磁珠和用于操纵和分类磁珠的电极，并集成到微流通道中。该设备旨在从直径9μm的磁珠上读取实时信号，这些磁珠在AMR传感器上移动，这些传感器被图案化为18 x 4.5μm矩形和10μm直径的环，并排列在惠斯通电桥中。珠子沿着SU8中形成的75 x 75μm宽通道在传感器上方移动。可以通过静磁分选门，利用载有0.2 A电流的经光刻压印的120 nm厚Cu带状线施加的磁场梯度，通过静磁分选门将其分类为微流体通道的不同分支。
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