Study of polyvinyl alcohol nanofibrous membrane by electrospinning as a magnetic nanoparticle delivery approach

摘要

Electrospinning technique was used to fabricate polyvinyl alcohol (PVA)-based magnetic biodegradable nanofibers. PVA solution was mixed with ferrofluid or magnetic nanoparticles (MNPs) powder and formed two individual nanofibrous membranes (PVA/ferrofluid and PVA/MNPs powder) by electrospinning. The surface morphology of the nanofibrous membrane was characterized by scanning electron microscopy and the magnetic properties were measured by vibrating sample magnetometer. Macrophages (RAW 264.7) were co-cultured with the nanofibrous membranes for 12, 24, and 48 h and exhibited good cell viability (＞95%). Results showed that the PVA fibers would be degraded and the embedded Fe_3O_4 nanoparticles would be released and delivered to cells.