Model Reactions of Thyroxine Biosynthesis. Identification of the Key Intermediates in Thyroxine Formation from 3,5-Diiodo-L-tyrosine and 4-Hydroxy-3,5-diiodophenylpyruvic Acid

摘要

In conclusion, we have isolated and rigorously characterized the reactive intermediates involved in thyroxine formation during the oxygenation of DIHPPA. Our study constitutes the first conclusive experimental proof that the intermediate is not 3-(4- hydroxy-3, 5-diiodophenyl)-3-hydroperoxy-2-oxopropionic acid (1) as was claimed, but rather it is the epoxides 8a and 9.