Palladium-Catalyzed Coupling of Optically Active Amines with Aryl Bromides

摘要

The coupling of enantiomerically enriched amines with aryl bromides produces the corresponding N-aryl derivatives. The choice of ligand in the palladium-catalyzed coupling is critical to the formation of anilines without loss of enantiomneric purity. While L_nPd(L=P(0-tolyl)_3)successfully catalyzes the intramolecular aryl amination of α-subsituted optically pure amines, intermolecular coupling reactions with this catalyst system gives raceemized products.