Rotational Barriers of cis/trans Isomerization of Proline Analogues and Their Catalysis by Cyclophilin

摘要

In addition, the ability of cytosolic porcine kidney cyclophilin (Cyp 18), a member of the peptidyl prolyl cis/trans isomerase family, to catalyze cis/trans isomerization of the peptide bond preceding the proline analogues was investigated. By line-shape analyses we proved efficient catalysis by Cyp 18 for the analogues Aze, 4-Thz, and 2-Thz.