A Pentacoordinate Oxorhenium(V) Metallochelate Elicits Antibody Catalysts for Phosphodiester Cleavage

摘要

In this communication we have reported the isolation of antibodies that cleave a phosphodiester bond. This finding further supports our hypothesis that oxoRe(V) complexes can be effective transition-state analogues for phosphoryl transfer reactions. Work is underway to isolate more efficient phos- phodiesterase antibodies by improving on the original hapten design.