DNA Damage from Sulfite Autoxidation Catalyzed by a Nickel(Ⅱ) Peptide

摘要

Guanine-specific modification of both single-and double-stranded oligodeoxynucleotides via the autoxidation of sulfite is shown to be catalyzed by [NiCR]~2+ (where CR=2, 12-dimethyl-3, 7, 11, 17-tetraazabicyclo[11.3.1]- heptadeca-1 (17), 2, 11, 13, 15-pentaene) and [NiKGH-NH_2]~+ (where KGH=lysylglycylhistidine). In the latter case, the nickel complex is proposed to act as a catalyst in three separate steps of sulfur oxide chemistry.