Comment on 'Self-Hardening Microspheres of Calcium Phosphate Cement with Collagen for Drug Delivery and Tissue Engineering in Bone Repair'

摘要

Recently, Park et al. described the addition of calcium phosphate into a stirred olive oil bath to produce microspheres of the same. Although the novelty of this communication is not questionable in using a paste-like mixture of a-TCP powders with collagen-containing Na2HPO4 setting solution, the process of obtaining microspheres, has been described previously. The process that involves introducing calcium phosphate, especially in combination with collagen, into a stirred olive oil bath was previously described by Hsu et al2 at 200, 350, 500, and 650 rpm and described by Sun et al? at 400 rpm. It must also be noted that Park et al.' only reported a constant stirring rate of the oil bath at 380 rpm, which was quite comparable to the stirring rates used in the above-mentioned previous studies.