Impact of Acyclovir on Genital and Plasma HIV-1 RNA, Genital Herpes Simplex Virus Type 2 DNA, and Ulcer Healing among HIV-1–Infected African Women with Herpes Ulcers: A Randomized Placebo-Controlled Trial

Philippe Mayaud1 Jérôme LeGoff34 Helen A. Weiss2 Gérard Grésenguet6 Khonde Nzambi7 Hicham Bouhlal3 Eric Frost8 Jacques Pépin8 Jean-Elie Malkin5 Richard J. Hayes2 David C. W. Mabey1 Laurent Bélec3 and for the ANRS 1212 Study Groupa

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Impact of Acyclovir on Genital and Plasma HIV-1 RNA, Genital Herpes Simplex Virus Type 2 DNA, and Ulcer Healing among HIV-1–Infected African Women with Herpes Ulcers: A Randomized Placebo-Controlled Trial

机译：阿昔洛韦对生殖器和血浆HIV-1 RNA，生殖器单纯性疱疹病毒2型DNA以及感染HIV-1的非洲妇女患有疱疹的溃疡愈合的影响：一项随机安慰剂对照试验

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BackgroundLittle is known about the impact of episodic treatment of herpes on human immunodeficiency virus type 1 (HIV-1)

机译：背景关于疱疹的间歇性治疗对人类免疫缺陷病毒1型（HIV-1）的影响知之甚少

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《Journal of Infectious Diseases》 |2009年第2期|p.216-226|共11页
作者
Philippe Mayaud1 Jérôme LeGoff34 Helen A. Weiss2 Gérard Grésenguet6 Khonde Nzambi7 Hicham Bouhlal3 Eric Frost8 Jacques Pépin8 Jean-Elie Malkin5 Richard J. Hayes2 David C. W. Mabey1 Laurent Bélec3 and for the ANRS 1212 Study Groupa;
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1Clinical Research Unit, Department of Infectious and Tropical Diseases, and 2Infectious Disease Epidemiology Unit, Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, United Kingdom;

3Université Paris Descartes, Equipe Immunité et Biothérapie Muqueuse, Unité INSERM Internationale U743 (Immunologie Humaine), Centre de Recherches Biomédicales des Cordeliers and Laboratoire de Virologie, Hôpital Européen Georges Pompidou, 4Université Paris Diderot, Laboratoire de Microbiologie, Hôpital Saint-Louis, and 5Centre Médical, Institut Pasteur, Paris, France;

6Centre National de Référence des Maladies Sexuellement Transmissibles et du SIDA de Bangui and Unité de Recherches et d’Intervention sur les Maladies Sexuellement Transmissibles et du SIDA, Faculté des Sciences de la Sa;

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1. Impact of acyclovir on genital and plasma HIV-1 RNA, genital herpes simplex virus type 2 DNA, and ulcer healing among HIV-1-infected African women with herpes ulcers: a randomized placebo-controlled trial. [J] . Mayaud P, Legoff J, Weiss HA The Journal of Infectious Diseases . 2009,第2期

机译：阿昔洛韦对生殖器和血浆HIV-1 RNA，生殖器单纯疱疹病毒2型DNA以及感染HIV-1的非洲疱疹妇女的溃疡愈合的影响：一项随机安慰剂对照试验。
2. Clinical and virologic response to episodic acyclovir for genital ulcers among HIV-1 seronegative, herpes simplex virus type 2 seropositive African women: a randomized, placebo-controlled trial. [J] . Baeten JM, Reid SE, Delany Moretlwe S, Sexually transmitted diseases . 2012,第1期

机译：HIV-1血清阴性，单纯疱疹病毒2型血清阳性非洲妇女生殖器溃疡对偶发性阿昔洛韦的临床和病毒学应答：一项随机，安慰剂对照试验。
3. Herpes simplex virus (HSV)-suppressive therapy decreases plasma and genital HIV-1 levels in HSV-2/HIV-1 coinfected women: a randomized, placebo-controlled, cross-over trial. [J] . Baeten JM, Strick LB, Lucchetti A, The Journal of Infectious Diseases . 2008,第12期

机译：单纯疱疹病毒（HSV）抑制疗法可降低HSV-2 / HIV-1合并感染妇女的血浆和生殖器HIV-1水平：一项随机，安慰剂对照，交叉试验。
4. Treatment of relapse in herpes simplex on labial and facial areas and of primary herpes simplex on genital areas and "area pudenda" with low-power He-Ne laser or Acyclovir administered orally [C] . Mariano Velez-Gonzalez, Hospital del Mar, Barcelona, Effects of Low-Power Light on Biological Systems . 1996

机译：口服低功率He-Ne激光或阿昔洛韦治疗阴唇和面部单纯疱疹复发，生殖器和单纯性疱疹复发
5. Genital herpes in high risk HIV-1 infected and HIV-1 uninfected women in US: Quantitative and qualitative evaluation of HSV infection and its interaction with HIV-1. [D] . Aumakhan, Bulbulgul. 2010

机译：美国高危HIV-1感染和HIV-1未感染妇女的生殖器疱疹：HSV感染及其与HIV-1相互作用的定量和定性评估。
6. Herpes Simplex Virus Suppressive Therapy Decreases Plasma and Genital HIV-1 Levels in HSV-2/HIV-1 Co-infected Women: A Randomized Placebo-Controlled Cross-Over Trial [O] . Jared M. Baeten, Lara B. Strick, Aldo Lucchetti, -1

机译：单纯疱疹病毒抑制疗法降低HSV-2 / HIV-1共感染妇女的血浆和生殖器HIV-1水平：一项随机安慰剂对照交叉试验
7. Impact of aciclovir on genital and plasma HIV-1 RNA in HSV-2/HIV-1 co-infected women: a randomized placebo-controlled trial in South Africa [O] . Sinéad Delany, Nonkululeko Mlaba, Tim Clayton, 2009

机译：ACICLOVIR对HSV-2 / HIV-1共感染妇女生殖器和血浆HIV-1 RNA的影响：南非随机安慰剂对照试验

Impact of Acyclovir on Genital and Plasma HIV-1 RNA, Genital Herpes Simplex Virus Type 2 DNA, and Ulcer Healing among HIV-1–Infected African Women with Herpes Ulcers: A Randomized Placebo-Controlled Trial

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