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An actively decoupled dual transceiver coil system for continuous ASL at 7 T

机译:有源去耦双收发器线圈系统,用于在7 T连续ASL

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摘要

7 T arterial spin labeling (ASL) faces major challenges including the increased specific absorption rate (SAR) and increased B-0 and B-1 inhomogeneity. This work describes the design and implementation of a dual-coil system that allows for continuous ASL (CASL) at 7 T. This system consisted of an actively detunable eight-channel transceiver head coil, and a three-channel transceiver labeling coil. Four experiments were performed in 5 healthy subjects: (i) to demonstrate that active detuning during ASL labeling reduces magnetization transfer; (ii) to measure the B-1 profile at the labeling plane; (iii) to quantify B-0 off-resonance at the labeling plane; and (iv) to collect in vivo CASL data. The magnetization transfer ratio in the head coil was reduced to 0.0 +/- 0.2% by active detuning during labeling. The measured B-1 profiles in all 5 subjects were sufficient to satisfy the flow-driven adiabatic inversion necessary for CASL, however the actual labeling efficiency was significantly impacted by B-0 off-resonance at the labeling plane. The measured CASL percent signal change in gray matter (0.94%+/- 0.10%) corresponds with the low labeling efficiency predicted by the B-0 off-resonance. This work demonstrates progress in the technical implementation of 7 T CASL, and reinforces the need for improved B-0 homogeneity at the labeling plane.
机译:7 T动脉自旋标记(ASL)面临着主要挑战,包括比吸收率(SAR)增加和B-0和B-1不均匀性增加。这项工作描述了双线圈系统的设计和实现,该系统允许在7 T时连续ASL(CASL)。该系统由一个可主动失谐的八通道收发器头线圈和一个三通道收发器标签线圈组成。在5名健康受试者中进行了四个实验:(i)证明ASL标记过程中的主动失谐会减少磁化传递; (ii)在标签平面上测量B-1轮廓; (iii)量化标签平面上的B-0共振; (iv)收集体内CASL数据。通过在标记过程中主动失谐,磁头线圈中的磁化传递比率降低到0.0 +/- 0.2%。在所有5位受试者中测得的B-1谱图足以满足CASL所需的流动驱动的绝热反演,但是,实际的标记效率受到标记平面B-0共振的影响。测得的灰质CASL信号百分数变化(0.94%+ /-0.10%)与B-0失谐预测的低标记效率相对应。这项工作证明了7 T CASL的技术实施进展,并加强了在标签平面上改善B-0均匀性的需求。

著录项

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  • 作者单位

    Univ Penn, Dept Radiol, Philadelphia, PA 19104 USA|Univ Penn, Ctr Funct Neuroimaging, Philadelphia, PA 19104 USA|Univ Calgary, Dept Clin Neurosci, Calgary, AB, Canada;

    Gachon Univ, Neurosci Res Inst, Inchon, South Korea|Seoul Natl Univ, Dept Elect & Comp Engn, Seoul, South Korea|Univ Minnesota, Sch Med, Ctr Magnet Resonance Res, Minneapolis, MN 55455 USA;

    Univ Penn, Dept Radiol, Philadelphia, PA 19104 USA|Univ Penn, Ctr Funct Neuroimaging, Philadelphia, PA 19104 USA|Cleveland Clin, Imaging Inst, Cleveland, OH 44106 USA;

    Univ Penn, Dept Radiol, Philadelphia, PA 19104 USA|Univ Penn, Ctr Funct Neuroimaging, Philadelphia, PA 19104 USA|Univ Penn, Dept Neurol, Philadelphia, PA 19104 USA;

    Siemens Healthcare, Siemens Med Solut USA Inc, New York, NY USA;

    Gachon Univ, Neurosci Res Inst, Inchon, South Korea;

    Univ Penn, Dept Radiol, Philadelphia, PA 19104 USA|Univ Penn, Ctr Funct Neuroimaging, Philadelphia, PA 19104 USA|Univ Penn, Dept Neurol, Philadelphia, PA 19104 USA;

    Gachon Univ, Neurosci Res Inst, Inchon, South Korea|Seoul Natl Univ, Adv Inst Convergence Technol, Seoul, South Korea;

    Univ Penn, Dept Radiol, Philadelphia, PA 19104 USA|Univ Penn, Ctr Funct Neuroimaging, Philadelphia, PA 19104 USA|Seoul Natl Univ, Dept Elect & Comp Engn, Seoul, South Korea;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    magnetic resonance imaging; arterial spin labeling; 7 T; specific absorption rate; labeling coils; B-1-mapping; B-0-mapping;

    机译:磁共振成像;动脉自旋标记;7 T;比吸收率;标记线圈;B-1映射;B-0映射;
  • 入库时间 2022-08-17 13:34:44

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