Histone deacetylase inhibitor augments anti-tumor effect of gemcitabine and pegylated interferon-α on pancreatic cancer cells

Shuichi Iwahashi; Mitsuo Shimada; Tohru Utsunomiya; Yuji Morine; Satoru Imura; Tetsuya Ikemoto; Hiroki Mori; Jun Hanaoka; Koji Sugimoto; Yu Saito

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Histone deacetylase inhibitor augments anti-tumor effect of gemcitabine and pegylated interferon-α on pancreatic cancer cells

机译：组蛋白脱乙酰基酶抑制剂增强吉西他滨和聚乙二醇化干扰素-α对胰腺癌细胞的抗肿瘤作用

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Histone deacetylase (HDAC) is strongly associated with epigenetic regulation and carcinogenesis, and its inhibitor can induce the differentiation or apoptosis of cancer cells.

机译：组蛋白脱乙酰基酶（HDAC）与表观遗传调控和致癌作用密切相关，其抑制剂可诱导癌细胞的分化或凋亡。

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来源
《International Journal of Clinical Oncology》 |2011年第6期|p.671-678|共8页
作者
Shuichi Iwahashi; Mitsuo Shimada; Tohru Utsunomiya; Yuji Morine; Satoru Imura; Tetsuya Ikemoto; Hiroki Mori; Jun Hanaoka; Koji Sugimoto; Yu Saito;
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作者单位

Department of Surgery, Institute of Health Biosciences, The University of Tokushima Graduate School, 3-18-15 Kuramoto-cho, Tokushima City, 770-8503, Japan;

Department of Surgery, Institute of Health Biosciences, The University of Tokushima Graduate School, 3-18-15 Kuramoto-cho, Tokushima City, 770-8503, Japan;

Department of Surgery, Institute of Health Biosciences, The University of Tokushima Graduate School, 3-18-15 Kuramoto-cho, Tokushima City, 770-8503, Japan;

Department of Surgery, Institute of Health Biosciences, The University of Tokushima Graduate School, 3-18-15 Kuramoto-cho, Tokushima City, 770-8503, Japan;

Department of Surgery, Institute of Health Biosciences, The University of Tokushima Graduate School, 3-18-15 Kuramoto-cho, Tokushima City, 770-8503, Japan;

Department of Surgery, Institute of Health Biosciences, The University of Tokushima Graduate School, 3-18-15 Kuramoto-cho;

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正文语种 eng
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关键词
Pancreas cancer; HDAC inhibitor; Valproic acid; Gemcitabine; Pegylated interferon-α;

机译：胰腺癌;HDAC抑制剂;丙戊酸;吉西他滨;聚乙二醇干扰素-α;
入库时间 2022-08-18 00:10:35

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专利

1. Histone deacetylase inhibitor augments anti-tumor effect of gemcitabine and pegylated interferon-α on pancreatic cancer cells [J] . IwahashiS., ShimadaM., UtsunomiyaT., International journal of clinical oncology . 2011,第6期

机译：组蛋白脱乙酰基酶抑制剂增强吉西他滨和聚乙二醇化干扰素-α对胰腺癌细胞的抗肿瘤作用
2. The Histone Deacetylase Inhibitor Valproic Acid Sensitizes Gemcitabine-Induced Cytotoxicity in Gemcitabine-Resistant Pancreatic Cancer Cells Possibly Through Inhibition of the DNA Repair Protein Gamma-H2AX [J] . Wang Yufeng, Kuramitsu Yasuhiro, Kitagawa Takao, Targeted oncology . 2015,第4期

机译：组蛋白脱乙酰基酶抑制剂丙戊酸可通过抑制DNA修复蛋白Gamma-H2AX来诱导吉西他滨耐药的胰腺癌细胞中的吉西他滨诱导的细胞毒性。
3. Chidamide, a novel histone deacetylase inhibitor, synergistically enhances gemcitabine cytotoxicity in pancreatic cancer cells [J] . QiaoZ., RenS., LiW., Biochemical and Biophysical Research Communications . 2013,第1期

机译：新型组蛋白脱乙酰基酶抑制剂Chidamide协同增强了吉西他滨对胰腺癌细胞的细胞毒性
4. Effect of Cromolyn in PEGylated Liposome in Combination with Gemcitabine for Pancreatic Cancer [C] . Min Ji Koo, Cha Eun Kim, Hye Jin Kim, Annual meeting exposition of the Controlled Release Society . 2011

机译：克罗莫林联合吉西他滨在聚乙二醇化脂质体中对胰腺癌的作用
5. The Molecular Mechanism of Histone Deacetylase (HDAC) Inhibitor PCI-24781 as an Anti-tumor Agent in Neuroblastoma Cells. [D] . Zhan, Qinglei. 2014

机译：组蛋白脱乙酰基酶（HDAC）抑制剂PCI-24781作为神经母细胞瘤细胞中抗肿瘤剂的分子机制。
6. Gemcitabine resistant pancreatic cancer cell lines acquire an invasive phenotype with collateral hypersensitivity to histone deacetylase inhibitors [O] . Betty K Samulitis, Kelvin W Pond, Erika Pond, 2015

机译：吉西他滨耐药胰腺癌细胞系具有侵入性表型对组蛋白脱乙酰基酶抑制剂有附带超敏反应
7. The Histone Deacetylase Inhibitor Suberoylanilide Hydroxamic Acid Induces Growth Inhibition and Enhances Gemcitabine-Induced Cell Death in Pancreatic Cancer [O] . Nichole Boyer Arnold, Nohea Arkus, Jason Gunn, 2007

机译：组蛋白脱乙酰化酶抑制剂Suberlanilide羟肟酸诱导生长抑制，增强胰腺癌中的吉西众林诱导的细胞死亡

Histone deacetylase inhibitor augments anti-tumor effect of gemcitabine and pegylated interferon-α on pancreatic cancer cells

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