Synthesis and Characterization of Neodymium(III) and Gadolinium(III)-Substituted Hydroxyapatite as Biomaterials

摘要

Nanocrystalline hydroxyapatite (HA), Ca_10(PO_4)_6(OH)_2, substituted with gadolinium (III) (Gd~(3+)) and neodymium(III) (Nd~(3+)) in different mole ratios (M_(added)/Ca_(added) = X_m, 0.01, 0.05, 0.1, and 0.2), was synthesized by an ion-exchange method. All samples had the single phase of HA except for X_M = 0.2, which displayed the second phase of M(OH)_3. All were B-type carbonated HA. The nanoparticles were elongated spheroids of around 70 nm, and the shape and size did not change significantly with an increase of X_m- The M(III)-doped HA had higher electrical conductivity compared with pure HA. A cytotoxicity test showed all were noncytotoxic except for X_(Gd) = 0.2.