Conformational analysis and μ-opioid receptor affinity of short peptides, endomorphin models in a low polarity solvent

Giuliana Cardillo; Luca Gentilucci; Alessandra Tolomelli; Ahmed R. Qasem; Santi Spampinato; Maria Calienni

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Conformational analysis and μ-opioid receptor affinity of short peptides, endomorphin models in a low polarity solvent

机译：低极性溶剂中短肽，内啡肽模型的构象分析和μ阿片受体亲和力

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Peptide carbamates containing the sequence H-Pro-Trp-PheNH_2 showed in CDCl_3 restricted conformations stabilized by the presence of a γ-turn. To test the reliability of the peptides as endomorphin conformational models, we measured the affinities for μ-receptors labelled with [~3H]-DAMGO. In particular, Cbz-Pro-Trp-PheNH_2 displayed a nanomolar affinity.

机译：含有序列H-Pro-Trp-PheNH_2的氨基甲酸酯肽在CDCl_3限制的构象中显示，可通过γ转角稳定化。为了测试肽作为内啡肽构象模型的可靠性，我们测量了用[〜3H] -DAMGO标记的μ受体的亲和力。特别地，Cbz-Pro-Trp-PheNH_2显示出纳摩尔亲和力。

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《INFOR》 |2003年第17期|p.3010-3014|共5页
作者
Giuliana Cardillo; Luca Gentilucci; Alessandra Tolomelli; Ahmed R. Qasem; Santi Spampinato; Maria Calienni;
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作者单位

Dipartimento di Chimica "G. Ciamician", C.S.F.M., Universita di Bologna, via Selmi 2, 40126-Bologna, Italy;

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收录信息美国《科学引文索引》(SCI);美国《工程索引》(EI);
原文格式 PDF
正文语种 eng
中图分类计算技术、计算机技术;
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入库时间 2022-08-18 00:19:42

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1. Conformational analysis and μ-opioid receptor affinity of short peptides, endomorphin models in a low polarity solvent [J] . Giuliana Cardillo, Luca Gentilucci, Alessandra Tolomelli, Organic & biomolecular chemistry . 2003,第17期

机译：低极性溶剂中短肽，内啡肽模型的构象分析和μ阿片受体亲和力
2. Recent advances in the investigation of the bioactive conformation of peptides active at the micro-opioid receptor. conformational analysis of endomorphins. [J] . Gentilucci L, Tolomelli A Current topics in medicinal chemistry . 2004,第1期

机译：在微阿片受体上有活性的肽的生物活性构象研究的最新进展。内啡肽的构象分析。
3. Recent Advances in the Investigation of the Bioactive Conformation of Peptides Active at the μ-opioid Receptor. Conformational Analysis of Endomorphins [J] . Luca Gentilucci Alessandra Tolomelli Current Topics in Medicinal Chemistry . 2004,第1期

机译：在μ阿片受体上有活性的肽的生物活性构象研究的最新进展。内啡肽的构象分析
4. SYNTHESIS AND BINDING ACTIVITIES FOR THE OPIOID RECEPTORS OF ENDOMORPHIN AND MORPHICEPTIN ANALOGS CONTAINING CONFORMATIONALLY CONSTRAINED 1- AMINOCYCLOALKANE-1-CARBOXYLIC ACIDS [C] . Takashi Yamada, Seiji Hakogi, Mirei Iino the European Peptide Symposium . 2007

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6. Endomorphin 1 and Endomorphin 2 Suppress in vitro Antibody Formation at Ultra-low Concentrations: Anti-Peptide Antibodies But Not Opioid Antagonists Block the Activity [O] . Benito Anton, Phillipe Leff, Juan C. Calva, -1

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Conformational analysis and μ-opioid receptor affinity of short peptides, endomorphin models in a low polarity solvent

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