Studies in antiparasitic agents: Part 24-Synthesis of 5-(2-furyl)-2-substituted-amino-1,3,4-triazoles and substituted 1,3,4-triazolo[1,5-a]-pyrimidines as potential antifilarial and leishmanicidal agents

摘要

A series of 5-(2-furyl)-2-substituted-amino-1,3,4-triazoles (3-5) and 2-(2-furyl)-1,3,4-triazolo[1,5-a]pyrimidines (6, 9-19) have been synthesized as possible inhibitors of antioxidant enzymes in filarii-ds and leishmanial parasites. All the compounds have been evaluated for their antifilarial and anti-leishmanial activities. The antifilarial activity has been evaluated against Litomosoides carinii infection in cotton rats while the in vitro leishmanicidal activity determined using macrophage amastigote culture isolated from cotton rats infected with Leishmania donovani. In both the tests none of the compounds exhibits any noteworthy antiparasitic activity.