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Three-Dimensional Multi-Frequency Shear Wave Absolute Vibro-Elastography (3D S-WAVE) With a Matrix Array Transducer: Implementation and Preliminary In Vivo Study of the Liver

机译:具有矩阵阵列换能器的三维多频剪切波绝对振动 - 弹性显影(3D S波):实施和肝脏体内研究的实施和初步

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Magnetic resonance elastography (MRE) is commonly regarded as the imaging-based gold-standard for liver fibrosis staging, comparable to biopsy. While ultrasound-based elastography methods for liver fibrosis staging have been developed, they are confined to a 1D or a 2D region of interest and to a limited depth. 3D Shear Wave Absolute Vibro-Elastography (S-WAVE) is a steady- state, external excitation, volumetric elastography technique that is similar to MRE, but has the additional advantage ofmulti-frequency excitation. We present a novel ultrasound matrix array implementation of S-WAVE that takes advantage of 3D imaging. We use a matrix array transducer to sample axial multi-frequency steady-state tissue motion over a volume, using a Color Power Angiography sequence. Tissue motion with the frequency components {40, 50, 60} and {45, 55, 65} Hz are acquired over a (90 degrees lateral)x(40 degrees elevational)x(16 cm depth) sector with an acquisition time of 12 seconds. We compute the elasticity map in 3D using local spatial frequency estimation. We characterize this new approach in tissue phantoms against measurements obtainedwith transient elastography and MRE. Six healthy volunteers and eight patients with chronic liver disease were imaged. Their MRE and S-WAVE volumes were aligned using T1 to B-mode registration for direct comparison in common regions of interest. S-WAVE and MRE results are correlated with R-2 = 0.92, while MRE and TE results are correlated with R-2 = 0.71. Our findings show that S-WAVE with matrix array has the potential to deliver a similar assessment of liver fibrosis as MRE in a more accessible, inexpensive way, to a broader set of patients.
机译:磁共振弹性显影(MRE)通常被认为是肝纤维化分段的成像的金标准,可与活组织检查相当。虽然已经开发出用于肝纤维化分段的超声基弹性成像方法,但它们被限制在1D或2D感兴趣区域和有限的深度。 3D剪切波绝对振动术(S波)是一种稳态,外部励磁,体积的弹性摄影技术,类似于MRE,但具有多频激励的额外优势。我们提出了一种新颖的超声矩阵阵列的S波的实现,其利用3D成像。我们使用矩阵阵列换能器以使用彩色功率血管造影序列在体积上采样轴向多频稳态组织运动。与频率分量{40,50,60}和{45,55,65} Hz的组织运动以(90度)X(40度)X(16cm深度)扇区获得,采集时间为12秒。我们使用局部空间频率估计计算3D中的弹性图。我们在组织幻影中表征了这种新方法,针对瞬态弹性摄影和MRE获得的测量。六名健康志愿者和八名慢性肝病患者成像。它们的MRE和S波容积使用T1对准到B模式注册,以便在普通的感兴趣区域中直接比较。 S波和MRE结果与R-2 = 0.92相关,而MRE和TE结果与R-2 = 0.71相关。我们的研究结果表明,具有矩阵阵列的S波有可能在更广泛的患者中以更容易获得的,更便宜的方式提供类似的肝纤维化评估。

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