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Effects of Pulsed Magnetic Field on the Flowing Red Blood Cells Using Microvascular Model

机译:微血管模型对脉冲磁场对流动红细胞的影响

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We have investigated quantitatively the effects of pulsed magnetic field (PMF) stimulus on the changes of blood flow, aggregation of red blood cells (RBCs), and oxidative stress on RBCs in the micro-channel of $15~mu ext{m}$ in diameter, in order to understand rheological properties of RBC in the microcirculation system. Erythrocyte sedimentation rate analysis was applied to see the effect of PMF on RBCs aggregation. RBCs disaggregated after PMF stimulus were sedimented slowly compared to that before PMF. It is also observed that after PMF stimulus, aggregation of RBCs is almost loosened, and the velocity of RBCs is fast in the microvascular model. Changes in blood flow and deformation of RBCs were examined after inducing oxidative stress to the erythrocyte membrane in order to see how the magnetic field affects the oxygen transport capacity of RBCs. From our results, PMF stimulus is proposed to achieve improvement of RBCs aggregation, increase of blood velocity, and preventing RBCs from oxidative stress.
机译:我们定量研究了脉冲磁场(PMF)刺激对$ 15〜 mu text {>微通道中微通道血流量,红细胞(RBC)聚集和氧化应激的影响。为了了解RBC在微循环系统中的流变特性,其直径为m} $。应用红细胞沉降速率分析来观察PMF对RBC聚集的影响。与PMF之前相比,PMF刺激后沉降的RBC缓慢沉降。还观察到,在PMF刺激之后,在微血管模型中,RBC的聚集几乎放松,并且RBC的速度快。在将氧化应激诱导至红细胞膜后,检查了RBC的血流变化和变形,以了解磁场如何影响RBC的氧转运能力。根据我们的结果,提出PMF刺激可以改善RBC的聚集,提高血流速度并防止RBC遭受氧化应激。

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