Cytokine Profile in Volunteers during a 21-Day Dry Immersion without Countermeasures

摘要

We studied the cytokine profile in ten healthy volunteers participating in the experiment with a 21-day-long dry immersion (DI). The results of these studies revealed pronounced individual differences in the immune system response to the prolonged exposure to simulated microgravity. It has been shown that the stay under the DI conditions leads to changes in the plasma cytokine levels, primarily towards their higher concentrations, and TH1/TH2 balance, as well as the activation potential of monocytes, which is manifested as a decrease in the synthesis of cytokines by cells with the TLR~(+)CD14~(+)phenotype in response to stimulation by various ligands in vitro.