Parameters of the Innate and Adaptive Immunity in Cosmonauts after Long-Term Space Flight on Board the International Space Station

摘要

The results of the study of the innate and adaptive immunity indicators in 12 cosmonauts who took part in long-term (128-215 days) expeditions on board the International Space Station (ISS) are presented. It was shown that the space flight may lead to deviations in the human immune system. A decrease in the functional activity of phagocytes, NK and T-cells, as well as in the ability of immunocompetent cells to synthesize cytokines were observed. Significant individual changes were observed in the immune system's response to a long-term space flight, which indicated an individual's predisposition to the development of immune reactivity disorders under varying gravitation conditions.