In the last few years, impressive research has been done on disorders of sex development (DSD), largely expanding the physiopathology with relevant effects on practice. Thus, man-agement of individuals with DSD requires up-dated scientific knowledge, integrating basic and clinical information. In addition, doctors involved in the care of individuals with DSD need to develop specific personal skills in com-munication, ethics, legal issues and the ability to work together in dedicated multidisci-plinary teams. National or even international networks are also mandatory to create strin-gent structures for correctly addressing the care of individuals with DSD and to offer them a better long-term outcome.
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