β Blockade in congestive heart failure: persistent adverse haemodynamic effects during chronic treatment with subsequent doses

摘要

Conclusions-Adverse haemodynamic ef- fects of β blockers in heart failure persist during chronic treatment, as shown by worsening haemodynamic indices with subsequent doses. Objective-To determine whether the Acute adverse haemodynamic effects of β Blockade in patients with congestive heart Failure persist during chronic treatment. Design-Sequential haemodynamic evalu- Ation of heart failure patients at baseline And after three months of continuous Treatment with the β_1 selective antagonist Metoprolol.