Systematic trial of pacing to prevent atrial fibrillation (STOP-AF)

摘要

The association of tachycardias with bradycardias was recognised almost 90 years ago, and has since been termed the brady-tachy syndrome, which in turn is one part of the sick sinus syndrome. Sinus node dysfunction is a major component of this syndrome, although the mecha- nism by which it is associated with either atrial arrhyth- mias or supraventricular tachycardia is not clear. Adenosine has been proposed as common mediator. In the past, patients with sick sinus syndrome have Often received pacemakers either to prevent spontaneously Occurring pauses, or to allow the prescription of antiar- Rhythmic drugs, given to reduce the frequency of or to Prevent atrial arrhythmias, but which may have the Unwanted side effect of exacerbating bradycardia.