Myocardial oxygen supply: demand ratio as reference for coronary vasodilatory drug effects in humans

摘要

Conclusions-Quantification of coronary vasoactive properties in relation to the physiological reference ratio between myocardial oxygen supply and demand may be a powerful tool to differentiate between true and apparent coronary vasoactive drugs. Objective-Introduction and measure- Ment of human myocardial oxygen sup- Ply: demand ratio as a reference for Quantification of coronary microvascular Vasodilating drug effects in clinical study- Ies. Myocardial oxygen consumption is The major determinant of coronary blood Flow; therefore, the true vasodilating Properties of coronary vasodilating drugs That may have an effect on oxygen con- Sumption cannot be correctly assessed From blood flow changes alone.